Modra MUROVSKA
Born: July 16, 1949, Saldus, Latvia
Interests:
- Virology, human retroviruses and
regulation of their replication, antisense polynucleotides as inhibitors of virus
replication
- Persistent viral (human herpesviruses
– CMV, HHV-6, -7, human parvovirus B19), infections, virus reactivation against
immunosuppression background
- Implication of viral infections in
the pathogenesis of autoimmune and chronic inflammatory diseases
- Molecular epidemiology of
Parvoviruses and sequence variability correlation with different clinical manifestations
Languages: Latvian, Russian, English - fluent, German - read and
translate.
Education
MD, Riga Medical Institute /Medical Academy of Latvia/ (Faculty of Pediatrics), 1972
Dr.med. (Candidate of Science in former USSR system, Ph.D. in Western countries), Cancer
Research Centre, USSR Academy of Medical Sciences, Moscow, Russia,1978
Experience
August
Kirchenstein Institute of Microbiology and Virology:
- Associate Professor, 2012 -
- Acting Director, Senior Researcher,
2006 -
- Head of the Laboratory of
Oncovirology, Senior Researcher, 1986-2006
- Senior Researcher, 1981-1986
- Junior Researcher, 1974-1981
- Postgraduate, 1973-1976
- Senior laboratory assistant, 1972-1973
Studies abroad and professional qualification:-
Certificate of the Association of Latvian
physicians in Clinical microbiology (1995-2005 - 2010 - 2015)
Guest Researcher, Department of Haematology, University
of Cambridge, 2001
Guest Researcher, Department of Medical Sciences, Uppsala
University (Scholarship of the Swedish Institute), 1998
Training: HTLV Phylogenetic Analysis, Katholieke
Universiteit Leuven, Belgium, 1996
Nordic Medical Council fellowship holder, Department of
Virology, the National Veterinary Institute, Uppsala, Sweden, 1993-1994
Japanese Society for the Promotion of Science fellowship
holder, Kochi Medical School, National Cancer Centre Research Institute, Institute of
Atomic Diseases of Nagasaki University Medical School, Japan, 1986-1987; 1989-1990.
Honours and Awards
Corresponding Member, Latvian Academy of Sciences, 2004
American Society for Microbiology Morrison Rogosa Award, 2000
The Latvian Academy of Sciences Presidium First Award, 1986
The Latvian Academy of Sciences Presidium Second Award, 1978
Professional Activities and Memberships
Association of Latvian Scientists
Latvian Association of Medical Microbiologists
Latvian Association of Haematologists
American Society for Microbiology
European Society for Virology
European Association for Cancer
Research
International Association for Chronic
Fatigue Syndrome (IACFS/ME)
Member, Latvian Council of Science Experts’
Committee for Molecular Biology, Biotechnology, Microbiology and Virology, 1993 –
2003
Member, Latvian Council of Science Experts’
Committee for Medicine, 2003-2007
Member, Latvian Council of Sciences Joint Experts’ Committee for Biology and
Medicine, 2003-2010
Member, Scientific Council of Riga
Stradinš University, 2007 -
Chairwoman, Scientific Council of
A.Kirchenstein Institute of Microbiology and Virology, Riga Stradinš University, 2007
–
Member, Latvian Council of Science
Experts’ Committee for Biology and Medicine, 2007-
Expert of European Commission Expert Group on Food and
Health Research, 2008-2011
Nominated delegate, Committee for the
FP7 Specific Program “Cooperation”, Theme 1 Health, 2010 –
Nominated representative in EDCTP,
2010 -
Vice Chair, Latvian Council of
Sciences Experts’ Committee for Biology and Medicine, 2010-2012
Member, Latvian Council of Sciences
Commission of Scientific Expertise, 2010 –
Member, Editorial Board of the
Journal Medicina (Kaunas), 2011 -
Chairwoman, Latvian Council of
Sciences Experts’ Committee for Biology and Medicine, 2012
Nominated representative in JPI
„Healthy Diet for Health Life” management committee, 2012 -
Publications: 134 original papers, 6 review papers and one monograph
Recent/Representative Publications
- M.Murovska, S.Lejniece, S.Kozireva. M.Koulikovska, H.Yin, J.Blomberg. Human
retrovirus 5 sequences in peripheral blood cells of patients with B-cell
non-Hodgkin’s lymphoma. - Int. J. Cancer, 2000, vol.85, 762-770.
- S.Chapenko, I.Folkmane, V.Tomsone, D.Amerika, R.Rozentals, M.Murovska.
Co-infection of two b-herpesviruses (CMV and HHV-7) as an increased risk factor for
“CMV disease” in patients undergoing renal transplantation. – Clin.
Transplantation, 2000, vol. 14, N 5, pp. 486-492
- M.Murovska, S.Kozireva, V.Tomsone. Antisense RNA-mediated
inhibition of bovine leukemia virus replication in transgenic rabbits. - Experimental
Oncology, 2001, vol.23, N 1, pp. 51-56.
- S.Chapenko, I.Folkmane, V.Tomsone, S.Kozireva, J.Bicans, D.Amerika,
R.Rozentals, M.Murovska. Infection of ß-herpesviruses
(CMV, HHV-6, HHV-7): Role in postrenal transplantation complications. -Transplantation
Proceedings, 2001, vol.33, N 4, pp. 2463-2464.
- S.Kozireva, S.Lejniece, J.Blomberg, M.Murovska. Human retrovirus
type 5 sequences in non-Hodgkin’s lymphoma of T cell origin. - AIDS Research and
Human Retroviruses, 2001, vol.17, N 10, pp. 953-956.
- V.Tomsone, I.Logina, A.Millers, S.Chapenko, S.Kozireva, M.Murovska.
Association of human herpesvirus 6 and human herpesvirus 7 with demyelinating diseases of
the nervous system. - J. Neurovirol., 2001, vol. 7, N 6, pp. 564-569.
- Chapenko S., Millers A., Nora Z., Logina I., Kukaine R., Murovska
M. Correlation between HHV-6 reactivation and multiple sclerosis disease activity. - J.
Med. Virol., 2003, 69(1): 111-117.
- Forsman A., Uzameckis D., Rönnblom L., Backlund E.,
Aleskog A., Bindra A., Pipkorn R., Lejniece S., Kozireva S., Murovska M., Blomberg
J. Single-tube nested quantitative PCR: a rational and sensitive technique for detection
of retroviral DNA. Application to RERV-H/HRV-5, and conformation of its rabbit origin. - J.
Virol. Methods, 2003, 111(1): 1-11.
- Murovska M., Kozireva S., Roce A., Danilane I.,
Mikazane H., Lejnieks A. Implication of HHV-6 in the pathogenesis of rheumatoid arthritis.
- Proc II European Congrss of Virology, Medimond, 2004, pp. 51-54.
- Kasyanov V., Isenburg J., ...., Murovska M.,
Halkes S.B., et al. Tannic acid mimicking dendrimers as small intestine submucosa
stabilizing nanomordants. - Biomaterials, 2006, vol.27, N 5, pp. 745-751.
- Chapenko S., Krumina A., Kozireva S., Nora Z., Sultanova A., Viksna L. Murovska M.
Activation of human herpesviruses 6 and 7 in patients with chronic fatigue syndrome. J
Clin Virol Suppl., 2006: S47-S51.
- Kozireva S.V., Zestkova J.V., Mikazane H.J., Kadisa A.L., Kakurina N.A., Lejnieks A.A.,
Danilane I.N., Murovska M.F.. Incidence and clinical significance of parvovirus B19
infection in patients with rheumatoid arthritis. J.Rheumatol., 2008, 35(7): 1265-1270.
- Chapenko S., Folkmane I., Ziedina I.,
Chistyakovs M., Rozentals R., Krumina A., Murovska M. Association of HHV-6 and
HHV-7 reactivation with the development of chronic allograft nephropathy. J. Clin.
Virol., 2009; 46: 29-32.
- Carruthers B.M., van de Sande M.I.,
... , Murovska M., Pall M.L., Stevens S. Myalgic encephalomyelitis: International
Consensus Criteria. J. Intern. Med., 2011;
270(4): 327-338.
- Nora-Krukle Z., Chapenko S., Logina
I., Millers A., Platkajis A., Murovska M. Human herpesvirus 6 and 7 reactivation
and disease activity in multiple sclerosis. Medicina
(Kaunas), 2011; 47(10): 527-531.
- Groma V., Kazanceva A., Nora-Krukle
Z., Murovska M. Oropharyngeal malignant epithelial cell, lymphocyte and macrophage
CD44 surface receptors for hyaluronate are expressed in sustained EBV infection:
Immunohistochemical data and EBV DNA tissue indices. Pathol.
Res. Pract., 2012, 208(9): 518-526.
- Capenko S, Kozireva S, Folkmane I,
Bernarde K, Rozentals R, Murovska M. Anemia as a complication of parvovirus b19
infection in renal transplant recipients. Medicina
(Kaunas), 2012, 48(6): 299-304.
- Chapenko S., Krumina A., Logina I.,
Rasa S., Chistjakovs M., Sultanova A., Viksna L., Murovska M. Association of active
human herpesvirus-6, -7 and parvovirus B19 infection with clinical outcomes in patients
with myalgic encephalomyelitis/chronic fatigue syndrome. Adv Virol, 2012; 2012:205085. Epub 2012 Aug 13 (DOI:10.1155/2012/2050850).
- Chapenko S., Trociukas I., Donina S.,
Chistyakov M, Sultanova A., Gravelsina S., Lejniece S., Murovska M. Relationship
between beta-herpesviruses reactivation and development of complications after autologous
peripheral blood stem cell transpalantaion. J. Med.
Virol., 9999:11-8 (2012) (DOI 10.1002/jmv.23412)
Guidance of Research Projects
- Establishing the framework to track
molecular epidemiology of Parvoviruses and to correlate sequence variability with
different clinical manifestations. (Principle Investigator) Cooperation Project of the Taiwan-Latvia-Lithuania
Mutual Funds (2012-2014)
- Interaction
between infectious agents and host genetic nature, Project of the National Research Program in Biomedicine
„“Development of new preventive, treatment, diagnostic means and methods,
biomedical technologies for improvement of public health” (Principle Investigator). Latvian
Council of Science (2010-2013)
- Investigation of etiopathogenesis of
chronic fatigue syndrome, post-infection and unspecified origin encephalopathy and
elaboration of diagnostic criterions (Principle Investigator). Latvian Council of
Science (2009-2012)
- Immunomodulating viruses, strategy of infection diagnostic and possibilities of therapy
correction”, project of the National Research Program „Investigation of major
pathologies endangering survival and life quality of Latvian inhabitants with the help of
multidisciplinary consortium” (Principal investigator). Latvian Council of Science
(2006-2009)
- Persistence of human parvovirus B19 (Principal investigator). Latvian Council of
Science (2004-2008)
- Role of persistent infection of ß-herpesviruses in etiopathogenesis of rheumatic and
inflammatory neural diseases (Principal investigator). Latvian Council of Science
(2004-2008)
- Involvement of the chemokine receptor genes identified within the human 3p21.3 region,
in haematological malignances (Head of Latvian Part of Project). The Royal Swedish
Academy of Sciences (2004)
- Human retroviruses: structure, properties (HRV-5) and replication control using
antisense approach (HTLV-I). Latvian Council of Science (2001-2003)
- Persisting viral infections and autoimmunity: implication of viruses in the pathogenesis
of autoimmune diseases. Latvian Council of Science (2001-2003)
- Role of Human Herpes Viruses and Human Retroviruses in the Development of Posttransplant
Complications. Swedish Institute in the frame of Visby Programme (2002, 2003)
- Involvement of the Chemokine Receptor Gene Cluster Identified within the Common
Eliminated Region 1 (CER1) on Human 3p21.3, in Haematological Malignancies. Swedish
Institute in the frame of Visby Programme (2001, 2002)
- Blood-borne Virus Infections in Latvia and Sweden. Swedish Institute in the frame of
Visby Programme (1998, 1999, 2000, 2001, 2002, 2003)
- Activation and Interaction of Herpesviruses (HCMV, HHV-6, HHV-7, HHV-8) against an
Immunosuppression Background. Molecular Epidemiology of HTLV-I/-II and Investigation of
Pathogenesis Mechanisms of Related Diseases. Latvian Council of Science (1997-2000)
- HTLV Group Virus/-es/ Spreading in Latvia, its/their/ Characteristics and Role in
Pathology, Methods of Diagnostics and Prophylactics. An Investigation of the Effect of
Antisense RNA Genes on Bovine Leukaemia Virus Reproduction in vitro and in vivo. Latvian
Council of Science (1991-1996)
- 9 Bachelor and Master of Science Works and 115 Promotion Works (5 presented)
- NorFA Course for PhD students of Nordic countries "Biology of Persistent and Latent
Viral Infections in Animals and Man", 1999
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Last update 15.11.2012
