
Lubov IGNATOVICH
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Dr.habil.chem. Lubov IGNATOVICH
Principal scientist
Head of the Laboratory of Organometallic Chemistry
Latvian Institute of Organic Synthesis
21, Aizkraukles str.,
Riga, LV-1006, LatviaPhone: +371 7553355; +371 29590575
e-mail: ign@osi.lv; luba@ignatovica.lv
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Born: 1953 July 8, Rezekne, Latvia
Interests:
- Organometallic (silicon, germanium, tin) chemistry
- Penta- and hexa-coordinated organosilicon and germanium compounds
- Chemistry of heterocycles (furan, thiophene, pyrimidine)
- Synthesis of biologically active compounds
Languages: Russian, Latvian, English
Education:
- University of Latvia (Faculty of Chemistry), 1976
- Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries),
Institute of Organic Synthesis, Riga, 1985
Thesis: "Synthesis and transformations of furylgermanes”
- Dr.habil.chem., University of Latvia, Riga, 1998
Thesis: “Synthesis, structure and biological activity of germyl- and
germaheterocycles”
Experience: Latvian Institute of Organic Synthesis –
- Scientific coworker, 1971-1976
- Engineer, 1976 -1981
- Junior Researcher, 1982-1985Researcher, 1985-1989
- Senior Researcher (Principal scientist), 1989 - 2009
- Head of the Laboratory of Organometallic Chemistry
Visiting researcher:
- ICIDCA, Habana, Cuba (Dr. Irma Castro-Mendez), 1988
- Cuban University, Habana, Cuba (Prof. Margarita Suaresh), 1989
- Tsukuba University, Tsukuba, Japan (Prof. Wataru Ando), 1990
- Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1991
- Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1992
- RIKEN, Sendai, Japan (Prof. Mitsuo Kira), 1993 -1994
- Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 1997
- Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 2001
Awards:
- The Latvian Academy of Sciences Presidium Award 1992
- Person of the Year Award (Marqui's Who's Who in the World), 2009
- Margus's Who's Who in Science and Engineering 2008 - 2009.
Plenary and invited Lectures:
- IV All-Union Conference on the Chemistry of Nitrogen-contaning Heterocyclic Compounds
(Novosibirsk, USSR), 1987
- XVII All-Union Conference on the Synthesis and Reactivity of Organic Compounds of Sulfur
(Tbilisi, USSR), 1989
- Tohoku University (Sendai, Japan), 1992
- University of Toulouse (France), 1994
- International Conference on environmental and biological aspects of main-group
organometals (ICEBAMO 94), Bordeaux (France), 1994
- 5th Blue Danube symposium on heterocyclic chemistry (5th BDSHC), Chasta-Papernicka
(Slovak Republic), 1995
- Nippon Soda Company, Odawara (Japan), 1997
- 5th International Conference on environmental and biological aspects of main-group
organometals, Schielleiten (Austria), 2001
- Uppsala University (Uppsala, Sweden), 2004
- 14th International Symposium on Organosilicon Chemistry, Wurzburg, (Germany), 2005
Representative Publications:
- Lukevics E., Gar T.K., Ignatovich L.M., Mironov V.F. Biological activity of
germanium compounds.- Riga: Zinatne,1990.-191p. (in Russian).
- Lukevics E., Ignatovich L. Uracil derivatives of Group 14 elements // Frontiers
of organogermanium, -tin and -lead chemistry / Ed. By E. Lukevics, L.Ignatovich. –
Riga: IOS,1993, 331-341.
- Lukevics E., Ignatovich L. Toxicity of organogermanium compounds. The chemistry
of organic germanium, tin and lead compounds / ed. By S. Patai. – Chichester: John
Wiley & Sons, 1995, 857-863.
- Belyakov S., Ignatovich L., Lukevics E. Concerning the transannular bond in
silatranes and germatranes: a quantum chemical study // J. Organomet. Chem. , 1999,
577, 205-210.
- Lukevics E., Ignatovich L., Belyakov S. Synthesis and molecular structure of
phenyl and tolylgermatranes // J. Organomet. Chem., 1999, 588, 222-230.
- Kira M., Ishida S., Ichinohe M., Kabuto C., Ignatovich L., Sakurai H. Synthesis
and structure of a stable cyclic dialkylgermylene // Chem. Letters ,1999, 263-264.
- Hashimoto H., Yagihashi Y., Ignatovich L., Kira M. Characterization and
properties of 1,2-Disiladigerma-cyclobutane // Heteroatom Chem., 2001, 12,.398-405.
- Ignatovich L., Zarina Dz., Shestakova I., Germane S., Lukevics E. Synthesis and
biological activity of silyl- and germylsubstituted trifluoroacetylfurans // Metal-Based
Drugs, 2002, 8, 211-214.
- Lukevics E., Ignatovich L. Biological activity of organogermanium compounds. The
Chemistry of Organic Germanium, Tin and Lead Compounds. Ed. Z.Rappoport, Chichester: John
Wiley & Sons Ltd. 2002, 1651-1683.
- Lukevics E., Ignatovich L, Shul’ga T., Belyakov S. Synthesis, molecular
structure and biological activity of bromobenzylgermatranes // J. Organomet. Chem.,
2002, 659, 165-171.
- Lukevics E., Ignatovich L., Shestakova I.Synthesis, psychotropic and anticancer
activity of
2,2-dimethyl-5-[5’-trialkylgermyl-(silyl)-2’-hetarylidene]-1,3-dioxane-4,6-diones
and their analogues //Appl. Organomet. Chem., 2003, 17, 898-905.
- Lukevics E., Ignatovich L. Biological Activity of Organosilicon Compounds.
Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine.
Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(5), 83-107.
- Lukevics E., Ignatovich L. Biological Activity of Organogermanium Compounds.
Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine.
Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(15), 279-295.
- Ignatovich L., Zarina D., Shestakova I., Germane S., Lukevics E. Synthesis and
biological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes.
Organosilicon Chemistry VI: Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA.
2005, From Molecules to Materials. Vol.1, Chapter 1, 563-568.
- Lukevics E., Ignatovich L., Sleiksha I., Shestakova I., Domrachova I., Popelis J.
Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes and
their thiosemicarbazones. //Appl. Organomet. Chem., 2005, 19, 1109-1113.
- Ignatovich L., Popelis J., Lukevics E. Synthesis and NMR spectra of dyaryl- and
dihetarylsilacycloalkanes. Organosilicon Chemistry VI: [Ed. by N.Auner and J.Weis.
Wiley-VCH Verlag GmbH&Co.KGaA]. 2005, From Molecules to Materials. Vol.1, Chapter 1,
559-562.
- Lukevics E., Ignatovich L., Sleiksha I., Muravenko V., Shestakova I., Belyakov
S., Popelis J. Synthesis, structure and cytotoxic activity of
2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. //Appl. Organomet. Chem., 2006,
20, 454-458.
- Ignatovich L., Muravenko V., Grinberga S., Lukevics E. Novel reactions to form an
Si-O-Ge group. // Chem. Heterocycl. Comp. , (Engl. Ed.). 2006, 42, 268-271.
- Lukevics E., Ignatovich L., Sleiksha I., Romanov V., Grinberga S., Popelis J.,
Shestakova I. New synthetic way to silicon and germanium containing 2-acetylfurans and
–thiophenes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, 43, 145-150.
- Lukevics E., Ignatovich L., Belyakov S. Disordering in crystal structures of
thienylgermatranes.// Chem. Heterocycl. Comp. (Engl. Ed.). 2007, 43, 243-249.
- Soualami S., Ignatovich L., Lukevics E., Ourari A., Jouikov V. Electrochemical
oxidation of benzylgermatranes.// J. Organomet. Chem., 2008, 693, 1346-1352.
- Lukevics E., Ignatovich L., Shul'ga T., Belyakov S. Synthesis and crystal
structure of 1-(4-fluorophenyl)- and 1-(4-dimethylamino)phenylgermatranes. // Chem.Heterocycl.
Comp. (Engl. Ed.)., 2008, 44, 615-620.
- Ignatovich L., Muravenko V., Shestakova I.,Domracheva I., Popelis J., Lukevics
E. Synthesis and cytotoxic activity of new
2-[(3-aminopropyl)dimethylsilyl]-5-triethylsilylfurans. //Appl. Organomet. Chem., 2010,
24(3), 158 - 161.
- Ignatovich L., Romanovs V., Shestakova I.,Domracheva I., Popelis J.,
Lukevics E. Synthesis and biological activity of new
2-[(3-aminopropyl)dimethylsilyl]-5-trialkylgermylfurans. //Khim. Geterocikl. Soed., 2009,
12, 1792-1799.
- Lukevics E., Abele E., Ignatovich L. Biologically Active Silacyclanes. //
In: Advances in Heterocyclic Chemistry, 2010, Vol. 99, 107-141.
- Soualmi
S., Ignatovich L., Jouikov V. Cation radicals of organogermatranes.// Appl. Organomet.
Chem. 2010, 24(12), 865-87.
- Ignatovich
L.,
Romanovs V., Spura J., Popelis J., Domracheva I., Shestakova I. Synthesis and antitumor
activity of 3-[(Methyl)bis(5-trialkylsilylfuran-2-yl)silyl]propylamines. //Chem.Heterocycl.Comp.
(Engl. Ed.), 2011, 47(12), 1502-1508.
- Ignatovich
L., Muravenko V., Spura J., Popelis J., Domrachova I., Shestakova I. Synthesis,
Structure and Cytotoxicity of New 2-[(3-Aminopropyl)dimethylsilyl]-5-furfural
Diethylacetals and 2-[(3-Aminopropyl)-dimethylsilyl]-5-phenylfurans. //Appl. Organomet.Chem., 2013, 27(7), 406-411.
- Ignatovich
L., Starkova O., Romanovs V., Sleiksha I., Shestakova I., Popelis J., Lukevics E.
Novel Trialkylsilyl(germyl)-substituted Thienyl- and Furylbenzimidazoles and their
N-Substituted Derivatives – Synthesis, Structure and Cytotoxic activity. //Comptes Rendus Chimie, 2013, 16(6), 521-627.
- Ignatovich L., Jouikov V. Organogermatranes and their cation radicals by EPR-spectroelectrochemistry and ab initio calculations. //J. Organomet. Chem. 2014, 751, 546-554. http://dx.doi.org/10.1016/j.jorganchem.2013.08.007
- Ignatovich L., Romanovs V., Muravenko V., Sleiksha I., Popelis J., Shestakova I. Synthesis and Cytotoxic Activity of 1-{3-[1-(5-Organylsilylfuran-2-yl)silinan-1-yl]propyl}amines and Some Trimethylgermyl Analogues. //Chem.-Eur. J. 2014, 20(40), 12786-12788.
- Ryabova V., Ignatovich L. Thiophene Substitution Chemistry. /DOI 10.1007/7081_2014_134/. Topics in Heterocyclic Chemistry 2015, Ed. John A Joule, Springer, Switzerland, Vol.39, 43-108.
- Ignatovich L., Spura J., Muravenko V., Beïakovs S., Popelis J., Shestakova I., Domrachova I, Gulbe A., Rudevica Z., Leonchik A. Synthesis, structure and biological activity of new 6,6-dimethyl-2-oxo-4-{2-[5-organylsilyl(germyl)]furan(thiophen)-2-yl}vinyl-5,6-dihydro-2H-pyran-3-carbonitriles. //Appl. Organomet. Chem. 2015, 29(11), 756-763.
Research Projects:
- L. Ignatovich (Head of Project). Unsaturated Heterocyclic Carbonyl Compounds as
Antitumor Agents. Latvian Taiho Foundation (1997 -1999).
- L. Ignatovich (Head of Project). Five Coordinated organogermanium Compounds as
Psychotropic and Anticancer Agents. Latvian Taiho Foundation (1999 -2001).
- L. Ignatovich (Head of Project). Diaphorase Activity Regulators: Role in Cancer
Chemotherapy. Latvian Taiho Foundation (2001 -2003).
- L. Ignatovich (Head of Project). Metal Complexes of Silyl and Germyl Substituted Oximes
and Thiosemicarbazones as Antitumour Agents Inhibiting Topoisomerase II. Latvian Taiho
Foundation (2003 -2005).
- L. Ignatovich (Head of Project).Carbofunctional Silylheterocycles. Latvian
Council of Science (2010 - 2012).
- L. Ignatovich (Head of Project).Organic derivatives of hypercoordinate germanium and
germyl(silyl)-heterocycles synthesis and investigation of properties (2013-2016).
- L. Ignatovich (WP 2 leader). Strengthening the research and innovation capacities of the
Latvian Institute of Organic Synthesis, the leading Baltic regional centre for drug
discovery. “InnovaBalt”. Project Coordinator – LIOS director, Professor
Ivars Kalvinsh. Project Manager – LIOS, Head of the Laboratory of Pharmaceutical
Pharmacology Dr. Maija Dambrova
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Last update 09.02.2016