Edmunds LUKEVICS

Professor Edmunds LUKEVICS Latvian Institute of Organic Synthesis, Head of the Laboratory of Organometallic Chemistry Aizkraukles iela 21, Riga, LV-1006 Latvia Phone: +371 7 553355 Fax: +371 7 550338 E-mail: sinta@osi.lv

Born: December 14, 1936, Liepaja, Latvia.

Interests:

• Organometallic Compounds
• Heterocyclic Compounds
• Biological Activity of Organic Compounds

Main Research:

Development of methods for the synthesis of organosilicon and -germanium derivatives of furan, thiophene and nitrogen-containing heterocycles ; study of the influence of organosilicon ,-germanium and -tin substituents on the direction of substitution and addition reactions of furan and thiophene derivatives ; study of hydrosilylation and hydrogermylation reactions, synthesis and investigation of properties of penta- and hexacoordinated organosilicon and -germanium derivatives; application of alkenyl silanes and germanes in the synthesis of nitrogen-containing heterocycles; application of phase-transfer catalysis and ultrasonic irradiation in organometallic synthesis; synthesis of biologically active organosilicon and organogermanium compounds and studies of their properties.

Education:

• University of Latvia (Faculty of Chemistry), 1958
• Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Latvian Academy of Sciences, Riga, 1966
• Dr.habil.chem. (Doctor of Science in former USSR), Latvian Academy of Sciences, Riga, 1973

Experience:

Latvian Institute of Organic Synthesis -

• Junior Researcher, 1958-1967
• Senior Researcher, 1968-1970
• Head, Laboratory of Organometallic Chemistry, 1970 -
• Vice-director, 1980-1982
• Director, 1982 - 2003

Honours and Awards:

• Corresponding Member, Latvian Academy of Sciences , 1982
• Full Member, Latvian Academy of Sciences , 1987
• Member, New York Academy of Sciences, 1993
• The Latvian Academy of Sciences Gustavs Vanags Prize (in Chemistry), 1986
• Latvian SSR State Prize, 1974, 1989
• S.Hiller Medal (Latvian Institute of Organic Synthesis), 1990
• G.Vanags Medal (Riga Technical University), 1991
• D.H.Grindel Medal (company ‘Grindex’, Latvia), 1995
• L.Liepina Medal (Institute of Inorganic Chemistry, Riga), 1996
• The Latvian Academy of Sciences Grand Medal, 1996
• Silver Medal of Milan University, 1996
• Schmiedebergs Medal (Latvian Pharmacological Society), 1998
• The Latvian Academy of Sciences and Company "GRINDEX" Prize, 1999
• Paul Walden's Medal (Riga Technical University), 2000
• Latvian Academy of Sciences Presidium Award, 1971, 1973, 1977, 1981, 1982, 1985,1987, 1989, 1992
• International Man of the Year (The International Biographic Centre of Cambridge, England), 1992-1993, 1994-1995
• Man of the Year (The American Biographical Institute), 1994, 2005
• The first-level Badge of Honour of the Order of Three Stars, 1997
• Company “Grindex” gold badge of honour, 2001
• The Cabinet of Ministers of the Republic of Latvia Prize , 2004
• American Medal of Honor (ABI), 2005
• Gold Medal for Latvia (ABI), 2006
• The Plato Award (IBC), 2006
• Man of Achievement (ABI), 2007

Professional Activities:

• Member of Presidium and Senate, Latvian Academy of Sciences, 1987-1991
• Member of Board, Division of Chemical and Biological Sciences, Latvian Academy of Sciences, 1983-1993
• Member, Latvian Academy of Sciences Commission on Terminology, 1987- 1999
• Chairman, Habilitation and Promotion Council (Chemistry and Pharmacy), Latvian Institute of Organic Synthesis, 1994 -1999
• Member (Chairman,1991-1993, 1997-2002), Latvian Council of Science Expert Committee for Chemistry, 1991 - 2006

• Vice-chairman, Habilitation and Promotion Council (Chemistry), University of Latvia, 1998-

• Member of Editorial Board for:

Khimiya Geterotsikicheskikh. Soedinenii (Chemistry of Heterocyclic Compounds, Springer), 1980-1985; Editor-in-chief, 1985 -
Proceedings of Latvian Academy of Sciences, 1982-1990
Latvian Journal of Chemistry, 1991 -
Bioorganicheskaya Khimiya, 1989 - 1993
Applied Organometallic Chemistry, 1990 -
Main Group Metal Chemistry, 1992 -
Metal-Based Drugs, 1993 - 2003
Mendeleev Communications, 1994 -
Advances in Heterocyclic Chemistry, 1994 -
Silicon Chemistry, 2001-2007
Arkivoc, 2001 -
Bioinorganic Chemistry and Applications, 2003 - 2006
Heterocyclic Communications, 2005 -

• Chairman, Scientific Council “Chemistry and Technology of Sulfur Organic Compounds”, USSR State Committee of Science and Technics, 1982-1987
• Chairman, Council “Application of Organometallic Compounds in National Economy”, USSR (Russian) Academy of Sciences, 1984-1992
• Member, United Libraries Informative Council, USSR Academy of Sciences, 1985-1990
• Member, Scientific Council “Physiologically Active Compounds”, USSR Academy of Sciences, 1986-1992
• Member, Scientific and Technical Council, USSR Ministry of Medical and Microbiological Industry, 1987-1990
• Member, Soviet National Committee on collecting and estimating information in science and technics “CODATA”, 1987-1990
• Member of Council for Coordination of scientific work, Department of Biochemistry, Biophysics and Physiologically Active Compounds, USSR Academy of Sciences, 1988-1991
• Member of International Organizing Committees
      - International Conference on the Coordination and Organometallic Chemistry of Germanium, Tin and Lead, 1992, 1995, 1998, 2001
      -  International Symposium on Organosilicon Chemistry, 1993, 1996, 1999, 2002, 2005, 2008.

Memberships:

• Member of Organometallic Chemistry Division, Federation of European Chemical Societies, 1995-2005
• Member of Organometallic Chemistry Division, European Association for Chemical & Molecular Sciences, 2006
• Member, Latvian Chemical Society, 1995
• Member, American Chemical Society, 1997
• Member, National Geographic Society, 1997
• Honorary Member,  Pharmacological Society of Latvia, 1998

Lectures

Invited Lectures at Universities

• Indian Institute of Science, Bangalore (India), 1989
• Indian Institute of Technology, Bombay (India), 1989
• University of Dresden (Germany), 1989
• Universities of Bordeaux, Tolouse, Montpellier, Marseilles (France), 1990, 1994
• University of Lund (Sweden), 1992
• University of Alcala de Henares ( Spain), 1993
• Tohoku University (Sendai, Japan), 1991, 1992
• Tokyo University of Science (Japan), 1997
• Kyoto University (Japan), 1997
• Universities of Kyoto and Kanagawa, Japan, 2002.

Invited Lectures and Symposium’s Plenary Lectures:

• 40th Nobel Symposium (Lidingö, Sweden), 1977
• VI Symposium on Chemistry of Heterocyclic Compounds (Brno, Czechoslovakia), 1978
• 7th International Symposium on Organosilicon Chemistry (Kyoto, Japan), 1984
• VI FECHEM Conference on Organometallic Chemistry (riga, Latvia), 1985
• II Soviet-Indian Symposium on Organometallic Chemistry( Irkutsk, Russia), 1989
• 17th DDR-Poland Colloquy on Organometallic Chemistry (Holzhau, Germany), 1989
• 6th International Conference on Organometallic and Coordination Chemistry of Germanium, Tin and Lead (Brussels, Belgium), 1989
• Huang Minlon Symposium on Organic Chemistry (Shanghai, China), 1989
• International Chemical Conference on Silicon and Tin ( Kuala Lumpur, Malaisia), 1989
• 9th International Symposium on Organosilicon Chemistry (Edinburgh, UK), 1990
• 1st Meeting of the European Society of Sonochemistry, Autrans (Grenoble, France), 1990
• 11th International Symposium on Medicinal Chemistry (Jerusalem, Israel), 1990
• S.Hiller Memorial Lectures (Riga, Latvia), 1990
• 1st Meeting of Japanese Germanium Discussion Group (Tokyo, Japan), 1991
• International Conference on Environmental and Biological Aspects of Maingroups Organometals (Padua, Italy), 1991
• 3rd Swedish-German workshop: Nucleic Acid Synthesis, Structure and Function (Uppsala, Sweden), 1992
• 2nd ANAIC Conference on Materials Science and Environmental Chemistry of Main Group Elements (Kual Lumpur, Malaysia), 1993
• Todai Symposium “Ge-Sn-Pb Tokyo’93”: International Symposium on Organic, Bioorganic and Bioinorganic Chemistry of Compounds of higher row Group 14-elements (Tokyo, Japan), 1993
• 10th International Symposium on Organosilicon Chemistry (Poznan, Poland), 1993
• 3rd Meeting of the European Society of Sonochemistry (Figueira da Foz, Portugal), 1993
• 14th Nordic Meeting of Structural Chemists (Helsinki, Finland), 1993
• 8th International Conference on the Organometallic Chemistry of Germanium, Tin and Lead (Sendai, Japan), 1995
• 8th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (Santa Barbara, USA), 1995
• 8th Symposium Heterocycles in Bioorganic Chemistry (Como, Italy), 1996
• 9th International Conference on the Coordination and Organometallic Chemistry of Germanium, Tin, and Lead (Melbourne, Australia), 1998
• 12th International Conference on Organosilicon Chemistry (Sendai, Japan), 1999
• International Conference on Organic Synthesis "Balticum Organicum Sinteticum-2000"(Vilnius, Lithuania), 2000
• X International Symposium "Jubilee Krka Prizes" (Novo Mesto, Slovenia), 2000

Recent/Representative Publications:

• E.Ya. Lukevits, M.G.Voronkov. Organic Insertion Reactions of Group IV Elements, 1966, New York: Consultants Bureau, 413 pp.
• S.N.Borisov, M.G.Voronkov, E.Ya.Lukevits. Organosilicon Heteropolymers and Heterocompounds, 1970, NewYork: Plenum Press, 633 pp.
• S.N.Borisov, M.G.Voronkov, E.Ya.Lukevits. Organosilicon Derivatives of Phosphorus and Sulfur, 1971, NewYork; London: Plenum Press, 343 pp.
• M.G.Voronkov, G.I..Zelchan, E.Ya.Lukevits. Silizium und Leben, 1975, Berlin: Akademie-Verlag, 370 pp.
• E.Lukevics, O.Pudova, R.Sturkovich. Molecular Structure of Organosilicon Compounds, 1989, Chichester: Ellis Horwood Ltd., 359 pp.
• E.Lukevics, T.Gar, L.Ignatovich, V.Mironov. Biological Activity of Germanium Compounds, 1990, Riga: Zinatne, 191 pp. (in Russian).
• E.Lukevics, A.Zablocka. Nucleoside Synthesis: Organosilicon Methods, 1991, Chichester: Ellis Horwood, 496 pp.
• E.Lukevics,  L.Ignatovich. Biological activity of organogermanium compounds. - In: The Chemistry of Organic Germanium, Tin and Lead Compounds/Ed. Z.Rappoport/, Wiley, Chichester, 2002, vol. 2, pt. 2, pp. 1653-1683.
• E.Lukevics,  O.Pudova. Biological activity of organogermanium compounds. - In: The Chemistry of Organic Germanium, Tin and Lead Compounds/Ed. Z.Rappoport/, Wiley, Chichester, 2002, vol. 2, pt. 2, pp. 1685-1714.

• E.Lukevics, O.Pudova. Silyl imidic esters. - In: Science of Synthesis, Thieme, 2002, vol. 4, pp. 305-315.
• E. Lukevics, P. Arsenyan, S. Belyakov, O. Pudova. Synthesis, structure and chemical transformations of ethynylgermatranes – Eur. J. Inorg. Chem., 2003, Iss.17, pp.3139-3143.
• R. Abele, E. Abele, M. Fleisher, S. Grinberga, E. Lukevics. Novel fluoride ion mediated synthesis of unsymmetrical siloxanes under phase transfer catalysis conditions. – J. Organomet. Chem., 2003, vol.686, N 1/2, pp.52-57.
• E. Lukevics, L. Ignatovich, I.Shestakova. Synthesis, psychotropic and anticancer activity of 2,2-dimethyl-5-[5-trialkylgermyl(silyl)-2’-hetarylidene]-1,3-dioxane-4,6-diones and their analogues. - Appl. Organomet. Chem., 2003, vol. 17, N 12, pp.898-905.
• P. Arsenyan, K. Rubina, I. Shestakova, E. Abele, R. Abele, I. Domracheva, A. Nesterova, J. Popelis, E. Lukevics. Synthesis and cytotoxicity of silylalkylthio-substituted N-heterocycles and their hydroselenites. – Appl. Organomet. Chem., 2003, vol. 17, N 11, pp.825-830.
• E. Lukevics, L. Ignatovich, T. Shul’ga, S. Belyakov. The crystal structure of 2-benzo[b]thienylgermatrane. – Appl. Organomet. Chem., 2003, vol. 17, N 9, pp.745-746.
• K. Rubina, E. Abele, P. Arsenyan, M. Fleisher, J. Popelis, A. Gaukhman, E. Lukevics. The role of palladium catalyst and base in stereoselective tranformations of (E)-2-chlorovinylsulfides. – Tetrahedron, 2003, vol.59, N 38, pp.7603-7607.
• I. Iovel, L. Golomba, J. Popelis, S. Grinberga, E. Lukevics Catalytic hydrosilylation of furan, thiophene, and pyridine aldimines. – Chem. Heterocycl. Comp., 2003, vol.39, N 1, pp.49-55.
• G. Veinberg, M. Vorona, I. Shestakova, I. Kanepe, E. Lukevics. Design of ß-lactams with mechanism based nonbacterial activities. – Current Medicinal Chemistry, 2003, vol.10, N 17, pp.1741-1757.
• E. Lukevics, P. Arsenyan, O. Pudova. Methods for the synthesis of oligothiophenes. – Heterocycles, 2003, vol.60, N 3, pp.663-687.
• V.Dirnens, V.Klusa, J.Skuyins, S.Svirskis, S.Germane, A.Kemme, E.Lukevics. Synthesis and pharmacological activity of silyl isoxazolines-2. - Silicon Chemistry, 2003 (publ. 2004), vol. 2, N 1/2, pp. 11-25.
• I.Iovel, L.Golomba, M.Fleischer, J.Popelis, S.Grinberga, E.Lukevics. Hydrosilylation of (hetero)aromatic aldimines in the presence of Pd(I) complex. - Chem.Heterocycl. Comp., 2004, vol. 40, N 6, pp. 701-714.
• P.Arsenyan, O.Pudova, J.Popelis, E.Lukevics. Novel radial oligothienylsilanes. - Tetrahedron Lett., 2004, vol. 45, N 15, pp. 3109-3111.
• E.Lukevics, L.Ignatovich, S.Belyakov. Crystallographic report: 2-furfurylgermatrane. - Appl. Organomet. Chem., 2004, vol. 18, N 4, p. 203.
• G. Veinberg, I. Shestakova, M. Vorona, I. Kanepe, E. Lukevics.  Synthesis of antitumor 6-alkylidenepenicillanate sulfones and related 3-alkylidene-2-azetidinones. -   Bioorg. Med. Chem. Letters, 2004, vol. 14, No 1, 147-150.
• E.Lukevics, L.Ignatovich, T.Shulga, S.Belyakov. 1-[4-(2-Thienyl)phenyl]germatrane. -   Appl. Organomet. Chem., 2005, vol. 19, N 1, pp. 167-168.
• E.Lukevics, L.Ignatovich. Biological activity of organosilicon compounds. - In:  Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine / Eds. M.Gielen, E.R.T.Tiekink/, 2005, J.Wiley & Sons, Ltd. Chichester, pp. 83-107.
• E.Lukevics, L.Ignatovich. Biological activity of organogermanium compounds. - In:  Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine / Eds. M.Gielen, E.R.T.Tiekink/, 2005, J.Wiley & Sons, Ltd. Chichester, pp. 279-295.
• Yu.Melnik, M.Vorona, G.Veinberg, J.Popelis, L.Ignatovich, E.Lukevics. Synthesis and stereoisomerization of 2-(1-alkoxyimino-2,2,2-trifluoroethyl)-5-trimethylsilylfurans. -   Chem. Heterocycl. Comp., 2005, vol. 41, N 6, pp. 718-721.
• L.Ignatovich, J.Popelis, E.Lukevics. Synthesis and NMR spectra of diaryl-  and dihetarylsilacycloalkanes. - In: Organosilicon Chemistry VI / Eds. N.Auner and J.Weis/, Wiley-VCH Weinheim, 2005, vol. 1, pp. 559-562.
• L.Ignatovich, D.Zarina, I.Shestakova, S.Germane, E.Lukevics. Synthesis and bological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes. - In: Organosilicon Chemistry VI / Eds. N.Auner and J.Weis/, Wiley-VCH Weinheim, 2005, vol. 1, pp. 563-568.
• E.Lukevics, L.Ignatovich, I.Sleiksha, I.Shestakova, I.Domrachova, J.Popelis. Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes. -  Appl. Organomet. Chem., 2005, vol. 19, N 10, pp. 1109-1113.
• S.Belyakov, E.Alksnis, V.Muravenko, I.Turovskis, J.Popelis, E.Lukevics. Crystal structure and conformation of 8-(2-hydroxyethylamino)-  and 8-(pyrrolidin-1-yl)adenosines. - Nucleosides, Nucleotides & Nucleic Acid, 2005, vol. 24, N 8, pp. 1199-1208.
• A. Zablotskaya, I.Segal, S.Belyakov, E.Lukevics. Silyl modification of biologically active compounds. 11. Synthesis, physico-chemical and biological evaluation of N-(trialkoxysilylalkyl)tetrahydro(iso,silaiso)quinoline derivatives. Appl. Organomet. Chem. 2006, vol.20, N 2, 149-159.  
• A.Zablotskaya, I.Segal, J.Popelis, E.Lukevics, S.Baluja, I.Shestakova, I.Domracheva. Silyl modification of biologically active compounds. 12. Silyl group as true incentive to antitumour and antibacterial action of choline and colamine analogues. - Appl. Organomet. Chem. 2006, vol. 20, N 11, 721-728.
• E.Lukevics, L.Ignatovich, I.Sleiksha, V.Muravenko, I.Shestakova, S.Belyakov, J.Popelis. Synthesis, structure and cytotoxic activity of 2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. - Appl. Organomet. Chem. 2006, vol 20, N 7, 454-458.   
• L.Ignatovich, V.Muravenko, S.Grinberga, E.Lukevics. Novel reactions to form an Si-O-Ge group. - Chem.Heterocycl. Comp., 2006, vol. 42, N 2, 268-271.  
• E.Lukevics, I.Shestakova, I.Domrachova, A.Nesterova, Y.Ashaks, D.Zaruma. Synthesis of complex compounds of methyl derivatives of 8-quinolineselenol with metals and their cytotoxic activity. - Chem.Heterocycl. Comp., 2006, vol. 42, N 1, 53-59.    
• E.Lukevics, L.Ignatovich, I.Sleiksha, V.Romanov, S.Grinberga, J.Popelis, I.Shestakova. A New method for the synthesis of silicon- and germanium-containing 2-acetylfurans and 2-acetylthiophenes. - Chem.Heterocycl. Comp., 2007, vol. 43, N 2, 143-150. 
• V.Dirnens, I.Skrastina, J.Popelis, E.Lukevics. Synthesis of isoxazolinylxanthines. - Chem.Heterocycl. Comp., 2007, vol. 43, N 2, 193-196.   
• E.Lukevics, L.Ignatovich, S.Belyakov. Disordering in the crystal structure of thienylgermatranes. - Chem.Heterocycl. Comp., 2007, vol. 43, N 2, 243-249.   
• E.Lukevics, I.Shestakova, I.Domrachova, E. Yashchenko, D.Zaruma. Y.Ashaks. Cytotoxic di(8-quinolyl)disulfides. - Chem.Heterocycl. Comp., 2007, vol. 43, N 5, 629-633.
• V.M.Vorona, I.Potorocina, G.Veinberg, I.Shestakova, I.Kanepe, M.Petrova, E. Liepinsh, E.Lukevics. Synthesis and structural modification of tert-butyl ester of 7a-chloro-2-(N,N-dimethylaminomethylene)-3-methyl-1,1-dioxoceph-3-em carboxylic acid.- Chem.Heterocycl. Comp., 2007, vol. 43, N 5, 646-652.
• A.Zablotskaya, I.Segal, E.Lukevics, S.Belyakov, H.Spies. Tetrahydroquinoline and tetrahydroisoquinoline mixed ligand rhenium complexes with the SNS/S donor atom set.- Appl.Organomet.Chem., 2007, vol.21, N 4, 288-293.
• A.Zablotskaya, I.Segal, M. Maiorov, D. Zablotsky, A. Mishnev E.Lukevics, I.Shestakova, I. Domracheva. Synthesis and characterization of nanoparticles with an iron oxide magnetic core and a biologically active trialkylsilylated aliphatic alkanolamine shell. J. Magn. Magn. Mater. 2007, 311, 135-139.      

Research Projects:

• E.Lukevics (Head of Project). Silylheterocycles in Organic Chemistry. Latvian Council of Science (1993-1995).
• E.Lukevics (Head of Project). Bifunctional Organosilicon Compounds. Latvian Council of Science (1993-1995).
• E.Lukevics (Head of Project). Synthesis of Heterocyclic Organosilicon and Organogermanium Compounds, Investigation of their Physical and Chemical Properties. Latvian Council of Science (1997-2000 ).
• E.Lukevics (Head of Project). Asymmetric and Catalytic Synthesis of Heteroaromatic Compounds. Latvian Council of Science (1997-2000 ).
• E.Lukevics (Head of Program). The Development of Modern Methods of Organic Chemistry Directed towards the Development of Pharmaceutical Industry in Latvia. Latvian Council of Science (1997-2000 ).
• E.Lukevics (Head of Project). Experimental and Theoretical Aspects of the Catalytical Synthesis of Heteroaromatic Compounds. Latvian Council of Science (2001 -2004 ).
• E.Lukevics (Head of Project). Comparative Study of the Structure and Biological Activity of Organosilicon and Organogermanium Compounds. Latvian Council of Science (2001 - 2004).
• E.Lukevics (Head of Project). Heterocyclic Derivatives of Tetra- and Hypercoordinated Germanium and Silicon. Latvian Council of Science (2005 -).
• E.Lukevics ( Programme Director). Development  of Organic Synthesis Methods for  Obtaining of Biologically Active Compounds. Latvian Council of Science (2002 -2005 ).
• E.Lukevics ( Programme Director). Development  of  Heteroatom Chemistry for Preparation of Biologically Active Compounds. Latvian Council of Science (2006 - ... ).

Hobbies:

Opera, Basketball, Mountains.

Last update 5.01.2007