Lubov IGNATOVICH


Dr.habil.chem. Lubov IGNATOVICH

Principal scientist
Laboratory of Organometallic Chemistry
Latvian Institute of Organic Synthesis

21, Aizkraukles str.,
Riga, LV-1006, Latvia

Phone: +371 7553355
e-mail: ign@osi.lv

 

 

Born: 1953 July 8,   Rezekne, Latvia

Interests:

  • Organometallic (silicon, germanium, tin) chemistry
  • Penta- and hexa-coordinated organosilicon and germanium compounds
    •
  • Chemistry of heterocycles (furan, thiophene, pyrimidine)
  • Synthesis of biologically active compounds

Languages: Russian, Latvian, English


Education:

  • University of Latvia (Faculty of Chemistry), 1976
  • Dr.chem. (Candidate of Science in former USSR, Ph.D. in Western countries), Institute of Organic Synthesis, Riga, 1985  
                       Thesis: "Synthesis and transformations of furylgermanes”
  • Dr.habil.chem., University of Latvia, Riga,   1998
                        Thesis: “Synthesis, structure and biological activity of germyl- and germaheterocycles”

Experience:

   Latvian Institute of Organic Synthesis –

  • Scientific coworker, 1971-1976
  • Engineer, 1976 -1981
  • Junior Researcher, 1982-1985Researcher,  1985-1989
  • Senior Researcher (Principal scientist),  1989 till now

  Visiting researcher:

  • ICIDCA, Habana, Cuba (Dr. Irma Castro-Mendez), 1988
  • Cuban University, Habana, Cuba (Prof. Margarita Suaresh), 1989
  • Tsukuba University, Tsukuba, Japan (Prof. Wataru Ando), 1990
  • Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1991
  • Tohoku University, Sendai, Japan (Prof. Hideki Sakurai), 1992
  • RIKEN, Sendai, Japan (Prof. Mitsuo Kira), 1993 -1994
  • Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 1997
  • Taiho Pharmaceutical Co., Ltd., Japan (Dr. Tetsuo Asao), 2001

Awards:

     The Latvian Academy of Sciences Presidium Award 1992

Plenary and invited Lectures:

  • IV All-Union Conference on the Chemistry of Nitrogen-contaning Heterocyclic Compounds (Novosibirsk, USSR), 1987
  • XVII All-Union Conference on the Synthesis and Reactivity of Organic Compounds of Sulfur (Tbilisi, USSR), 1989
  • Tohoku University (Sendai, Japan), 1992
  • University of Toulouse (France), 1994
  • International Conference on environmental and biological aspects of main-group organometals (ICEBAMO 94), Bordeaux (France), 1994
  • 5th Blue Danube symposium on heterocyclic chemistry (5th BDSHC), Chasta-Papernicka (Slovak Republic), 1995
  • Nippon Soda Company, Odawara (Japan), 1997
  • 5th International Conference on environmental and biological aspects of main-group organometals, Schielleiten (Austria), 2001
  • Uppsala University (Uppsala, Sweden), 2004
  • 14th International Symposium on Organosilicon Chemistry, Wurzburg, (Germany), 2005

Representative Publications:

  1. Lukevics E., Gar T.K., Ignatovich L.M., Mironov V.F. Biological activity of germanium compounds.- Riga: Zinatne,1990.-191p. (in Russian).
  2. Lukevics E., Ignatovich L. Uracil derivatives of Group 14 elements // Frontiers of organogermanium, -tin and -lead chemistry / Ed. By E. Lukevics, L.Ignatovich. – Riga: IOS,1993, 331-341.
  3. Lukevics E., Ignatovich L. Toxicity of organogermanium compounds. The chemistry of organic germanium, tin and lead compounds / ed. By S. Patai. – Chichester: John Wiley & Sons, 1995, 857-863.
  4. Belyakov S., Ignatovich L., Lukevics E. Concerning the transannular bond in silatranes and germatranes: a quantum chemical study // J. Organomet. Chem. , 1999, 577, 205-210.
  5. Lukevics E., Ignatovich L., Belyakov S. Synthesis and molecular structure of phenyl and tolylgermatranes // J. Organomet. Chem., 1999, 588, 222-230.
  6. Kira M., Ishida S., Ichinohe M., Kabuto C., Ignatovich L., Sakurai H. Synthesis and structure of a stable cyclic dialkylgermylene // Chem. Letters ,1999, 263-264.
  7. Hashimoto H., Yagihashi Y., Ignatovich L., Kira M. Characterization and properties of 1,2-Disiladigerma-cyclobutane // Heteroatom Chem., 2001, 12,.398-405.
  8. Ignatovich L., Zarina Dz., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silyl- and germylsubstituted trifluoroacetylfurans // Metal-Based Drugs, 2002, 8, 211-214.
  9. Lukevics E., Ignatovich L. Biological activity of organogermanium compounds. The Chemistry of Organic Germanium, Tin and Lead Compounds. Ed. Z.Rappoport, Chichester: John Wiley & Sons Ltd. 2002, 1651-1683.
  10. Lukevics E., Ignatovich L, Shul’ga T., Belyakov S. Synthesis, molecular structure and biological activity of bromobenzylgermatranes // J. Organomet. Chem., 2002, 659, 165-171.
  11. Lukevics E., Ignatovich L., Shestakova I.Synthesis, psychotropic and anticancer activity of 2,2-dimethyl-5-[5’-trialkylgermyl-(silyl)-2’-hetarylidene]-1,3-dioxane-4,6-diones and their analogues //Appl. Organomet. Chem., 2003, 17, 898-905.
  12. Lukevics E., Ignatovich L. Biological Activity of Organosilicon Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(5), 83-107.
  13. Lukevics E., Ignatovich L. Biological Activity of Organogermanium Compounds. Metallotherapeutic Drugs and Metal-Based Diagnostic Agents. The Use of Metals in Medicine. Ed. M.Gielen, E.R.T.Tiekink. J.Wiley & Sons, Ltd., 2005(15), 279-295.
  14. Ignatovich L., Zarina D., Shestakova I., Germane S., Lukevics E. Synthesis and biological activity of silicon derivatives of 2-trifluoroacetylfuran and their oximes. Organosilicon Chemistry VI: Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA. 2005, From Molecules to Materials. Vol.1, Chapter 1, 563-568.
  15. Lukevics E., Ignatovich L., Sleiksha I., Shestakova I., Domrachova I., Popelis J. Synthesis and cytotoxic activity of silacycloalkylsubstituted heterocyclic aldehydes and their thiosemicarbazones. //Appl. Organomet. Chem., 2005, 19, 1109-1113.
  16. Ignatovich L., Popelis J., Lukevics E. Synthesis and NMR spectra of dyaryl- and dihetarylsilacycloalkanes. Organosilicon Chemistry VI: [Ed. by N.Auner and J.Weis. Wiley-VCH Verlag GmbH&Co.KGaA]. 2005, From Molecules to Materials. Vol.1, Chapter 1, 559-562.
  17. Lukevics E., Ignatovich L., Sleiksha I., Muravenko V., Shestakova I., Belyakov S., Popelis J. Synthesis, structure and cytotoxic activity of 2-acetyl-5-trimethylsilylthiophene(furan) and their oximes. //Appl. Organomet. Chem., 2006, 20, 454-458.
  18. Ignatovich L., Muravenko V., Grinberga S., Lukevics E. Novel reactions to form an Si-O-Ge group. // Chem. Heterocycl. Comp. , (Engl. Ed.). 2006, 42, 268-271.
  19. Lukevics E., Ignatovich L., Sleiksha I., Romanov V., Grinberga S., Popelis J., Shestakova I. New synthetic way to silicon and germanium containing 2-acetylfurans and –thiophenes. // Chem.Heterocycl. Comp. (Engl. Ed.)., 2007, 43, 145-150.
  20. Lukevics E., Ignatovich L., Belyakov S. Disordering in crystal structures of thienylgermatranes.// Chem. Heterocycl. Comp. (Engl. Ed.). 2007, 43, 243-249.

Research Projects:

  • L. Ignatovich (Head of Project). Unsaturated Heterocyclic Carbonyl Compounds as Antitumor Agents. Latvian Taiho Foundation (1997 -1999).
  • L. Ignatovich (Head of Project). Five Coordinated organogermanium Compounds as Psychotropic and Anticancer Agents. Latvian Taiho Foundation (1999 -2001).
  • L. Ignatovich (Head of Project). Diaphorase Activity Regulators: Role in Cancer Chemotherapy. Latvian Taiho Foundation (2001 -2003).
  • L. Ignatovich (Head of Project). Metal Complexes of Silyl and Germyl Substituted Oximes and Thiosemicarbazones as Antitumour Agents Inhibiting Topoisomerase II. Latvian Taiho Foundation (2003 -2005).

 

Last update 16.11.2007